Sibiriak

Cocoa powder directly to coffee--I need to try that!

Surprising good news! Thanks Dean!

Clinton's back ! Yee haw! 😀

Clinical Effects of Regular Dry Sauna Bathing: A Systematic Review (2018) The Science & Health Benefits of Deliberate Heat Exposure | Huberman Lab (Video) (2022)

Thanks for the report. One question: is it only grape seed PACs that might have an impact on NAD levels, or could PACs from various berries possibly have such an effect as well? In any case, a major concern for me would be the possibility of long-term adverse effects from the chronic intake of very large amounts of PACs. Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes Antioxidant/Pro-Oxidant Actions of Polyphenols From Grapevine and Wine By-Products-Base for Complementary Therapy in Ischemic Heart Diseases

I'm not too worried about rogue AI. Our Leaders will take control of the technology and use it to the benefit all of humanity:

True, but there are definitely a number of non-genetic factors noted in mainstream medical research ( and few not so noted). For example, saturated fat intake vs carbohydrates. Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement (October, 2022)

Causal explanations are required. For example: Lipoprotein (a) is an interesting case. Lp(a) has been identified as a super-dangerous causal risk factor for cardiovascular disease, and pharmaceutical companies are going all out to develop drugs that reduce it (statins are ineffective). Nevertheless, Lp(a) may have anti-infection and anti-cancer functions (perhaps especially if combined with exercise), and may actually be a double-edged sword.

That's a lot! I'm curious, what product are you using?

Sorry to hear about this. As you likely already know, cranberry extract and d-mannose are moderately effective in preventing certain kinds of bacteria from adhering to the urinary track walls, but won't directly knock out an infection like antibiotics. They are probably most useful as prophylactics.

Huberman discusses red light therapy for eyesight here: The Science of Vision, Eye Health & Seeing Better https://youtu.be/ObtW353d5i0?t=4409 https://youtu.be/uWV9a3zEaL4?t=1807 (links jump to where red light discussion begins) You can also search for Professor Glen Jeffery (University College London, Institute of Ophthalmology) who apparently is the leading expert on the topic.

Sometimes I need to drive through a crowded city and out to a neighboring village. Driving conditions can be quite dangerous--icy roads + poor visibility + numerous reckless, non-law-abiding drivers to contend with. I want to be maximally alert and focused, and if I feel I need a boost, I use some or all of these aids: Ice-cold shower (1-3 reps/ with energizing breathing) Short duration/high intensity cold exposure-->long-lasting increase in dopamine and norepinephrine. Fortunately the tap water here is extremely cold, otherwise I’d probably go for a short ice bath. Coffee+cacao (sometimes green tea, if less caffeine preferred. Ideally I’d stop caffeine intake 10hrs before sleep time). Nicotine lozenge (occasionally, 1/2 or less) Enhances alertness via dopamine, acetylcholine, norepinephrine.

That's right. But Fontana does say that heart attack risk "approaches zero at an LDL level of about 57 mg/dl. "

A recent paper with lots of references: Mental Performance and Sport: Caffeine and Co-consumed Bioactive Ingredients (Nov. 2022) Discusses in detail caffeine, coffee, cacao, green tea, guarana, ginkgo biloba, ginseng, taurine, l-theanine etc.

Microbiota Effect on Trimethylamine N-Oxide Production: From Cancer to Fitness—A Practical Preventing Recommendation and Therapies (2023)