Clinton

Haha! Thanks - glad to be back

Thanks Drewab - things are improving every day. If my memory still serves me you are in Alberta ... I was born & raised in Grande Prairie, Alberta btw - I hope all is well with you and yours, Clinton

Thanks Dean - I'm glad to be back - I hope all is well with you of course! Clinton

Thanks Saul - I trust you are still teaching young whipper-snappers university math and getting your swims in??

Hey gents, I joined back in 2016 and kinda quit the forums back in May of 2022. At that time I went through a divorce - it left me devastated - I ended up scrapping the majority of my longevity regimen. I quit exercising, drank heavily for many months, lost my interest in eating much at all including healthy foods, had much difficulty sleeping and had lost interest in longevity 'research' and many other interests in my life. Over the past 4 months, I've met a new lady-friend and rekindled my interest in fitness, health and longevity - I remember and appreciate all of the usual suspects here and all of the well-researched and intelligent posts. I'm very grateful for all of the amazing information and people here that have helped me understand what I consider to be a healthy approach to healthspan and lifespan and I hope to soon begin contributing again to the forums, Sincerely, Clinton

https://www.longecity.org/forum/stacks/stack/122-michaels-tiered-supplement/ Read this. You need to keep track of what you eat using software; one option is the free chronometer app which is simple to use, then supplement only what you require to correct deficiencies. Zinc and B-vitamins I believe can generally be safely supplemented, but calcium from supplements as compared to getting it from food sources seems create some possible concerns. I would encourage you to read up on calcium supplements; they have been discussed on these forums.

Extremely simple approach- which imo could be slightly improved if a person logged their intake into the chronometer for micronutrient intake and slightly adjust some foods and supplements accordingly. Like Josh Mittledorf eats: Beans and Greens and lots of nuts!👍👍

Double post - sorry.

Edited

Exactly - thanks Gordo. And perhaps it should also state 'for weight loss alone but not all benefits'. This study only looked at weight loss and not other (imo very significant) improvements that might increase healthspan/lifespan. I.E. Even IF there was ZERO change in fat loss - check out these benefits from Rhonda Patrick interview w Tim Ferriss (studies done on HUMANS): Recent studies suggest that… • Eating within an 11-hour window was associated with a decreased breast cancer risk and reduction in recurrence by as much as 36%. • Earlier meal timing associates with improved effectiveness of weight-loss therapy in overweight and obese patients. • For each 3-hour increase in nighttime fasting duration was linked to a 20% lower odds of elevated glycated hemoglobin (HbA1C), which is a more long-term marker of blood glucose levels. • For each 10% increase in the proportion of calories consumed after 5pm there was a 3% increase in the inflammatory biomarker c-reactive protein otherwise known as CRP. • Eating one additional meal during the day (instead of the evening) was associated with an 8% decrease in CRP. • Eating within a 12-hour window improved sleep and increased weight loss in normal weight people.

Wow. So some key take-aways for anyone hoping to increase healthspan/lifespan in a pill (or augment your exercise, etc. with a supplement regimen): I came away from that hearing that there was zero evidence for fish oil, green tea, resveratrol, nicotinamide riboside (NR), NMN, spermidine (which we already know that diets high in spermidine for humans is THE most important micronutrient for lifespan), and unfortunately they were not able to test a stable form of sulforaphane. Quite interesting at the end he seemed enthused about astaxanthin ...

Ron, If you've read the study - maybe you're as intrigued about glycine as I am - something that improves sleeping, increases insulin sensitivity - examine has a review of it here based on 151 papers: Glycine Supplement — Health Benefits, Dosage, Side Effects | Examine.com It appears very safe ... at the moment.