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Last summer I rigged up a pool in the garden, for my son. However, he only used it a couple of times. So, I'm presently using it as a cold plunge. The temperatures are dropping and the water starts feeling coldish. Especially so this morning. I'm going to buy a water thermometer and some cleaning tools. And keep using it until possible or feasible. The plunge sure feels great but afterwards at times I feel myself anomalously hungry.

Based on the 900-day rule (which Kaberlein was a co-author), only 40% CR extended lifespan in the above-study... But the 40%CR group also faster for 2 days/week...

while thinking about feasibility of adding back some bakery into my diet to substitute fruits partially I used to do some free search and unexpectadly landed into a book "Nutrition, Food and Diet in Ageing and Longevity" Springer Nature, 2021 from which I became curious about the research done by Grant Rutledge (https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0240132&type=printable) which focused on so called Hamilton's hypothesys (which supports a lot of observations and recommendations about dietary choices in the midlife given in some sane books like those by Fontana and other respected authors). In a few words - after 40 years of selective experiments on melanogasters it looks plausible to hypothesise that "ancestral" diet (the one adopted 90%+ of the species timeline) could be preferential from the midlife in comparison to the novel one of the recent generations. Here is a talk on the topic: I wonder if somebody from the long-term practitioners have own data on inflamation markers being on a healthy diet with grains/cereals and without them, offcourse no artificial "foods" or keto regimens and other known modifiers (e.g. huge o6 intake that could also interfer). The experiment could take many months, thus it could be useful to learn other's anecdotes on the topic. UPDATE: a systematic review on crp and il6 markers during grain/nograin studies https://pmc.ncbi.nlm.nih.gov/articles/PMC8778110/ (seems in all the experiments it does matter what was the type of diet, some have clear zero effect and some halves the markers easily)

I started to supplement with L-carnosine, as part of Sandra Kauffman's Panacea protocol, which I modified a little. Kauffman's model is conceptually satisfying and she has cited a lot of research An interesting video on L-carnosine.

There doesn't seem to be a video about his opinion on the China Study. Wish he'd do one on that.

https://www.youtube.com/watch?v=iQHugpi8b7k

I'm a bigger fan of Michael Greger

just 2 cents on primate studies and conclusions for humans, I came to similar some time ago and now I've found them in a compact lecture form in The New Science of Healthy Aging (https://www.amazon.com/New-Science-Healthy-Aging/dp/1094077011) The conclusion in the chapter on monkeys/apes and us in brief - we evolved to be much more prepared for constant movement (but not intensive sports, just be active several hours/day) and the price for it - our bodies are damaged by our metabolism if we live the modern way (with its food and modus operandi). The key to understand this (one of the most importnant) came from Hadza studies (+similar for other last available then natural people) and a discovery that they do burn the same energy as a modern person (not with extremely expanded body!) but their energy seems is spent differently (including creation of less molecule types that do the harm in studied ways to the body). IMHO it is better to live that way in any case, trying to keep the smallest healthy bodyframe from the very beginning of life (no dairy in younger ages!) because striping the body later will not switch all the complicated interacting networks of metabolic complexity to their best possible result (the familiar one that is limited by 120 years but seems only for small people, e.g. 140-160cm usually and never expanded to unhealthy weight zones). Br, Igor

It looks like my kind of movie. I'll try to convince my wife to watch it.

I'm not going to freeze myself. I don't like being cold. I do, however, routinely go hiking up the mountain when it's 105 degrees or more, and that dirt road bakes in the heat. I'll often go 8 or 10 miles round trip. That's as far as I can go in the heat without a drink. I carry water but it's for my poor dog who needs a drink before we get back far more than I do. Lots of big hills on the Gladetop trail here in the Ozarks.

Good stuff. I plan to do DunedinPACE testing, would be nice to see lots more people doing this so we can actually have some solid evidence of value for different interventions.

I just looked her up and found she smoked and ate up to 2 pounds of chocolate a week! Yes! The goalpost is flawed! She surely would have lived even longer if she were applying the ideas we're aware of and applying today. So there has to be doubt about her representation of our potential lifespan. It has to be more than the 122 years achieved by a smoker who ate more than a quarter pound of chocolate a day!

Horvath Epigenetic Age: A Weak Spot, But I Have A Plan (14-Test Analysis)

A Higher Kynurenine/Tryptophan Ratio Is Associated With Lower Muscle Mass

Maybe not, Part II:

Definitely, and thanks drewab!

In this video, Mic examines whether refined sugar is linked to cancer. Although it's widely known that refined sugar is unhealthy and consumption is minimal for folks on this website, the topic is still intriguing (particularly the strength of the relationship and mechanism). The idea that "many cancer cells selectively depend on glucose for energy, potentially using 50-100 times more glucose than normal cells" is explored. There is also a fascinating paper which shows, contrary to some beliefs, that breast cancer cells can indeed use ketones for fuel. Mic also explores evidence suggesting that maintaining low fasting glucose levels is beneficial, which is expected as I suspect it's an overall marker of health and insulin sensitivity. Remarkably, one study indicated that metformin can reduce cancer incidence by 30-50%... which is insane! Among various types of cancer, the link between sugar intake and increased breast cancer risk appears to be the most substantiated. There's a lot packed into this video and it might be worth a watch. Maybe we'll see sugar get recognized as a carcinogen (or probably carcinogen) at some point... I sure hope so.

Although this article talks a lot about AD, I put it in this exercise thread because exercise remains the most potent behavioural therapeutic approach for the improvement of mitochondrial health Mitochondrial Boost Reverses Protein Clumping in Aging and Alzheimer’s · A core set of insoluble proteins is linked to both aging and Alzheimer’s. · Amyloid beta exacerbates protein clumping, creating a vicious cycle of decline. · Boosting mitochondrial health can reverse the toxic effects of protein clumping. [This] systematic study in worms that paints an intricate picture of the connections between insoluble proteins in neurodegenerative diseases and aging. the work demonstrated an intervention that could reverse the toxic effects of the aggregates by boosting mitochondrial health. “Our study shows how maintaining healthy mitochondria can combat protein clumping linked to both aging and Alzheimer’s,” said Manish Chamoli, PhD Furthermore, the work demonstrated an intervention that could reverse the toxic effects of the aggregates by boosting mitochondrial health. The strong link between insoluble proteins promoting normal aging and diseases also builds a case for the bigger picture of how aging and age-related diseases occur. Aging is driving the disease, but the factors that put you on the track toward the disease actually occur very early The fact that the team found a core insoluble proteome enriched with numerous proteins that had not been considered before creates new targets for exploration, said Lithgow. “In some ways it raises the flag about whether we should be thinking about what Alzheimer’s looks like in very young people,” he said. The focus of most research on Alzheimer’s disease to date has been targeting accumulations of two proteins: amyloid beta and tau. But there are actually thousands of other proteins in these insoluble aggregations, said Anderton, and their role in Alzheimer’s disease was unknown. They found that there is a subset of proteins that seem to be very vulnerable to becoming insoluble, either by adding amyloid beta or during the normal aging process. They called that vulnerable subset the “core insoluble proteome”. The team went on to demonstrate that the core insoluble proteome is full of proteins that have already been linked to different neurodegenerative diseases in addition to Alzheimer’s disease, including Parkinson’s disease, Huntington’s disease and prion disease. “Our paper shows that amyloid could be acting as a driver of this normal aging aggregation,” said Anderton. we’ve got clear evidence, I think for the first time, that both amyloid and aging are affecting the same proteins in a similar way. using Urolithin A, a natural gut metabolite produced when we eat raspberries, walnuts, and pomegranates which is known to improve mitochondrial function: it significantly delayed the toxic effects of amyloid beta. “Mitochondria have a strong link with aging. They’ve got a strong link with amyloid beta,” he said. “I think ours is one of the few studies that shows that insolubility and aggregation of those proteins might be the link between the two.” “Because the mitochondria are so central to all of this, one way to break the vicious cycle of decline is to replace damaged mitochondria with new mitochondria,” said Lithgow. “And how do you do that? You exercise and follow a healthy diet.”

And another interesting quot from the book, not related to dogs but to the topic of body size and longevity: this was about things not so murked out by very aggressive tactic adopted (and further developed) after tobacco war by "food" industry now to promote novadays body ideal, so sheds some light on data about excercising at athletes grade but in the age when there was no modern chemistry tricks and excercising was more focused on "to be" rather than "to look like", how unhealthy it could be now is an interesting question.

A curious review, no idea if it is not a kind of "eat more" conditioning: https://journalofmetabolichealth.org/index.php/jmh/article/view/78/242#CIT0060_78 Sometimes I think about pendulum, since it has moves "to the right" and "to the left" then a lot of things without a careful quantitative analysis (e.g. there are 40 studies that proves "a" without saying that there are 4000 studies that proves "non a" - who knows how many of them are in reality and what power they have in total, e.g. not just plain quantity but with weight coefficients) could be easyly used as manipulative language constructs (it moves to the left! it moves to the right! more research is required!) and this is heavily used in marketing of almost all we anyhow consume. From my observation I sometimes have acne after sudden evening overeating of carbs-heavy meal but I never tried to link it with salt, given a hard possibility to assess its real consumption. Generally, the stricter I am with evening energy - the less chance for acne to appear. On the other hand - I assume there should be a large group of people that do not benefit from low salt diets and for them perhaps it makes no sense to try to go down far from 3g/day for the sake of "safety", who knows to which levels their ancestry was tuned long time before (but 7g is also a bad idea, no natural tuning for such a value seems ever happened with homos). Br, Igor

Good collection of data!

No. You have not solved the problem of consciousness. You do not even know what the "problem" (i.e., consciousness) consists in. Name a single property of consciousness (necessary if treated to mathematical formalism and physical measurement). As I read more and more from these savants of sentience, I grow increasingly convinced that rational thought, for far too many, is at best, their second or third language.

Yesterday Chris Macaskill from Plant Chompers released a thoughtfully researched video titled "The Shocking Reality of High LDL Cholesterol." The video starts by exploring the nuisances of why insurance companies don't care about your high LDL cholesterol and briefly explores variables insurance companies in your policy eligibility (some variables here were quite surprising to me - particularly those that expose the patient to radiation like CT scans). Chris goes on to explore LDL/HDL cholesterol and it's association with disease, including through the Coppenhagen heart study. When all is said and done, the video is a great exploration of the "LDL is good for you bandwagon" that much of the internet seems to be on at the moment.

I'll be 85 yo in 6 weeks. I'm in excellent health, and have been practicing CR for about 30 years. I don't intend toexperiment with taking Rappa -- but I'm very interested in Matt Kaberlien's work on the effects of Rappa on large domestic dogs (which are short-lived mammals; it's a placebo controlled trial, that has been cleverly set up to not require approval by any government agencies -- people volunteer their pet dogs). -- Saul