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Thanks for sharing the report. Unfortunately Tricarico was not ready to ship to USA and refunded my order. I may try to track down an early harvest Picual or Cornicabra from Spain this year (they often seem to report 500-900 mg/kg polyphenols). I did try Bryan Johnson's Blueprint olive oil at a gathering recently; while the color was a very vibrant green I found the taste to be not significantly more robust than my 2022 harvest Oilala Coratina.

I'm pretty sure the low-mg dosage of most reputable lithium orotate supplements is reflecting the amount of elemental lithium. The bottle I have says "each capsule provides 1000mcg elemental lithium". Some products on Amazon clarify and say "130mg lithium orotate / 5mg elemental lithium"

Interesting. Do you know how it could be so much lower? I can't imagine harvest conditions changed enough to cut the phenolic content in half...perhaps they altered their testing method. I've come across a lot of other Italian Coratina oils that claim very high phenolic content. For example, this one https://www.agricolatricarico.it/products/baginboxdongiovanniolioextraverginebiologico-bboxdg claims 866 mg/kg. I just ordered 3L on ebay, though not sure it will actually ship to me.

Rebuttal: https://academic.oup.com/ajcn/article/103/6/1557/4569627?login=true More recent krill research seems to indicate reduction in atherosclerotic risk. See: https://drc.bmj.com/content/3/1/e000107.short https://academic.oup.com/nutritionreviews/article/75/5/361/3078064?login=true https://cms.galenos.com.tr/Uploads/Article_49041/ejcm-9-150-En.pdf https://academic.oup.com/nutritionreviews/article/78/9/699/5740623?login=true https://lipidworld.biomedcentral.com/articles/10.1186/s12944-015-0162-7 https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201700098

Any thoughts on sourcing an olive oil rich in DMB? DMB seems to be a promising molecule for reducing TMAO and inflammation. Not sure how much truth there is, but this article claims: “You don’t want most extra-virgin olive oil from Italy, because it doesn’t have much DMB in it,” he says. Instead, opt for oil from Turkey, Spain, Greece, or California. Other DMB-rich foods include balsamic vinegar, watermelon, and red wine."

You're correct, I tested it during exercise a few times and it basically just doesn't register heart rate variability well enough to be useful. It still works well for resting heart rate, and heart rate trends over time. The one I bought is no longer available on Amazon, but it's basically identical to this one: https://www.amazon.com/LCW-Temperature-Thermometer-Tracking-Waterproof/dp/B08HQRGZYJ/ I'm sure there are better ones out there in the same price range, and I can't really recommend cheaper smart watches unless you just want a 24-hour resting HR monitor. The battery life is very impressive though, most new cheap models easily last 10+ days on a charge. It's too bad there aren't a bunch of Chinese Oura ring competitors popping up, like there are with smart watches. Probably will see that within the next year or two.

Those are good points. The cheap Chinese watch I bought actually tests blood pressure every 10 minutes, and HR and body temperature are recorded every minute and logged in an app. I'm not optimistic about the blood pressure accuracy and I haven't tried to validate it yet against a cuff, but I did validate the heart rate monitor multiple times and it reads the same as both my pulse oximeter and Apple Watch Series 3. I will try some more extensive HR and BP validation tomorrow during exercise and see how it performs, but so far I'm satisfied with a $30, 24-hour heart rate monitor.

At the very least, Samsung Galaxy 3 watches have demonstrated high accuracy for BP measurements in a clinical setting, after calibration. Models sold outside the US have the blood pressure feature enabled, but it's blocked on the US sold products. There are currently dozens of smart watches capable of reading SpO2, temperature, and blood pressure on Amazon for >$50, and I assume they all have pretty similar tech inside. I'll get one soon and do some testing. Validation of Blood Pressure Measurement Using a Smartwatch in Patients With Parkinson's Disease

Just glancing at the sample menus, it's not exactly surprising. They were eating stuff like English muffins, strawberry fruit spread, and added sugar Greek yogurt in the higher carb groups, and trading those calories for olive oil and macadamia nuts, AND added 200+ grams of salad in the low carb group.

It's not about avoiding selenium altogether, but avoiding a massive selenium overdose. A single brazil can easily have 200% of the RDA. I was actually starting to doubt the old "dangerous brazil nut" lore myself, until I found this study (using just 3 to 6 nuts, 3x per week): Selenium status in preschool children receiving a Brazil nut–enriched diet Study highlights: "These children were asymptomatic, but at risk for toxicity"..."Children not receiving a supplemented diet had normal levels of selenium." That being said, 6 brazil nuts three times a week is a pretty big dose for a preschooler. Assuming a normal sized adult, that would be maybe 15 to 30 brazil nuts, 3 times a week, for a minimum of 7 months as per the study. And despite the long term high level consumption, none of the preschoolers demonstrated any toxicity symptoms.

The microcystin risk and heavy metal contamination is really a non-issue with spirulina. Spirulina has had GRAS recognition for years. Aphanizomenon flos-aquae is the algae that is much more frequently contaminated with cyanotoxins. However, is spirulina even suitable as a staple food? I don't think I would be comfortable consuming 100+ grams of it a day. Is 10+ grams of phycocyanin even healthy? I wouldn't want to be the lab rat there.

Slower, deeper breaths might have some stress reducing and HR/BP lowering effects. As long as you're not changing your blood oxygenation though, I really doubt it matters. I wouldn't want to wear a mask while I sleep, but don't see any real concern when you're awake and can consciously adjust your respiratory rate if you feel any oxygen starvation.

Maybe it is related to the high stearic acid content of cocoa butter. There is a lot of discussion on longecity about stearic acid's influence on mitochondrial fusion. Also of interest: https://mobile.twitter.com/matthewjdalby/status/1310966867566178307?lang=en

I think the ultra smooth appearance of his face is largely from the webcam quality. There are some other recent videos on Youtube where he looks like a normal mid-to-late 40s man. He has good hair, isn't overweight, and looks like he takes care of himself. That goes a long way to looking youthful. A more impressive example of youthful appearance in middle age is Chuando Tan, a 51 year old Korean who claims no plastic surgery and only once used botox around his eyes. https://www.youtube.com/watch?v=CRwV21mPXy0 I don't think skin youthfulness will be an early indicator of whether or not rejuvenation therapy is working. I have a hunch that things like the loss of subcutaneous fat and cross-linking of skin collagen won't be so quick to recover.

Humans did evolve around fires, breathing in some amounts of smoke on a regular basis. There are likely some hormetic benefits from low-level pollution. At what level of exposure you surpass the hormetic bell curve, is to be determined.