Saul

I'm on CR; I don't need or want semiglutide. -- Saul

I'll be 85 yo in 6 weeks. I'm in excellent health, and have been practicing CR for about 30 years. I don't intend toexperiment with taking Rappa -- but I'm very interested in Matt Kaberlien's work on the effects of Rappa on large domestic dogs (which are short-lived mammals; it's a placebo controlled trial, that has been cleverly set up to not require approval by any government agencies -- people volunteer their pet dogs). -- Saul

I agree. Kenton's comment makes sense, too. I have a complimentary subscription to the NYT (a courtesy extended to me by virtue of being a [fully employed] prof at the University of Rochester -- and I had been considering posting that same article to the NYT. -- Saul

Hi Ash! Dean's opinions about the monkey studies are just that: Dean's opinions. I wouldn't necessarily take them seriously. (Anyway, Dean's opinions work for Dean). -- Saul

I have a high opinion of Kaberlien, and a vry low opinion of Atiyah. -- Saul

I basically agree with Tom. I'm 84 3/4, in excellent health. I also agree with Cory's post, about Al's post, noting the inportance of adopting a creative and self-transcendent perspective on life can positively impact gene expression. Both of my brothers have passed away -- both my older brother and my younger brother. My parents, and all relatives that I know about, did not have extraordinary lifespans or healthspans. Like Tom, I exercise, though I don't enjoy it. I do enjoy calorie restriction, and have been practicing CR for a long time, and intend to continue doing so. -- Saul

Hi McCoy! Sounds like a ketotic diet. They do make it easy to lose weight; but Luigi, in his original posts, discouraged them. (Evidence is that the lipid levels tend to be bad.) Byt maybe it work well for you. -- Saul

Gordo, The immune suppressive factor in rapa is negligible for helthy people; so it's conceivable that rapa might be interesting. I asked Matt when he gave a talk at the University of Rochester's annual aging conference, whether he thought that CR and rapa might go together. He said that he never could get funding for such a study. The dog study is possible, since it simply depends on large dog owners volunteering to allow their pet to enter the study. Since large dogs have short lifespans, there hopefully might be some useful data in not too long a time period. If, as Matt suspects, rapa appears to improve the expected lifespan and heathspan of large dogs, it would certainly be interesting. -- Saul

IMO, breathing in nanoparticles is a very bad idea for your lungs. Much less clear is, whether or not eating foods containing nanoparticles of plastics is a significant threat to health (obviously depends ona lot of factors -- including what plastic; how big are the pieces; etc). Animal studies would be interesting. But I would guess: Giving up your raw broccoli, because maybe there are inert nonoplastic particles in it, is unwise. -- Saul

Very believable. -- Saul

I believe that you're almost certainly correct. -- Saul

I'm participating in a series of 8 meetings of about 10 people (faculty, grad students; med school plus college of arts and sciences) on AI. My favorite tool is Microsoft Bing Copilot; IMO, it's the best. (Possibly, I'll be able to use it to write Midterm Exams easiy:) Happily, I think University of Rochester is getting a site license. -- Saul

It seems extremely likely to me that each of our organs ages at a different rate; and that these rates differ for different people. I've seen good articles on this topic in the past; here's IMO a good one posted today in the Wall Street Journal: https://www.wsj.com/health/wellness/aging-biological-age-organs-health-9b6a4798?mod=hp_lead_pos11 -- Saul

I would guess that, the younger the animal, the more pro-growth stuff -- bad for adults seeking increased healthspan and lifespan. And no animal is younger then an egg. -- Saul

No comment. I don't think much of any Guru's thoughts, no matter how many videos they make. -- Saul

I don't supplement taurine, but almost always have excellent sleep. Probably the most important sleep cycle is the non-REM (deep sleep) cycle. My sleep habits improved strongly after I took an MBSR course (Mindfully Based Stress Relief), offered free to employees of the University of Rochester. A good meditative practice (I practice insight meditation -- different from the types of meditation covered in the MBSR course.) is probably helpful Yogic breathing exercises are also helpful. -- Saul

I drink Chinese imported white tea. -- Saul

I use a device that was chosen by the NHI for their "AllOfUs" study. The device is the Fitbit Versa 4. It gives results for HR (as you experience it); the values that if gives seem plaudible to me. (I'll see my nephrologist sometime in the next few months -- he checks my bloodwork, etc. [Note: I have excellent kidney function; I was fortunate to get regular appointments with a nephrologist for bloodwork. I'll ask him about the accuracy of the fitbit's HR readings -- they go to my cellphone, and can be easily viewed]. Unfortunately, the fitbit doesn't track BP -- not a surprise -- that should be hard to do on a wrist device (but not impossible -- of course, wrist BP will vary greatly, according to the position of your wrist). -- Saul

Interesting read. -- Saul

Great, Matt!

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Agreed. Better still, look at some of the less biased vegan gurus (including the "nearly vegans") who eat small amounts of animal products. Good example: Khurram HaShimi. -- Saul

Fungi are more related to Animals than plants. -- Saul

Yep. I'm still fully employed (teaching 2 courses in the Fall, 2 in the Spring) at UR -- tenured Full Prof.; not interested in retiring (would be boring). But, I no longer swim -- I used to swim with my own invented stroke -- a lousy stroke; it ate up my rotator cuffs. I had a successful shoulder replacement of the right shoulder -- but no more swimming. So, for exercise, I do vigorous exercise on an elliptical cross trainer at a high resistance, 6 days a week. -- Saul

That's great Clinton! Glad to hear it! -- Saul