Mikii

Hunter gatherer cholesterol levels are generally suppressed by parasitic infections, they commonly have at least one their entire lives. That may even be why we evolved cholesterol levels high enough to cause atherosclerosis, the short term trade off of better resistance to parasites. Blood lipids, infection, and inflammatory markers in the Tsimane of Bolivia Role of cholesterol in parasitic infections Serum lipids and lipoproteins in malaria - a systematic review and meta-analysis

Haven’t seen anyone mention yet the difference between the hydrophilic and lipophilic statins - the hydrophilic ones (rosuva, prava, fluva) have more selectivity for the liver and do not easily enter peripheral cells. They also do not cross the blood brain barrier (since dementia is linked to high cholesterol this may actually be a detriment, but if your priority is avoiding any potential statin side effects on the brain it’s the low risk choice). Doctors I have seen discuss this seem to mainly prescribe rosuvastatin (Crestor), then try pravastatin if someone has side effects from Crestor. Hydrophilic or Lipophilic Statins?

The first concern would be the possibility of being exposed to morphine/codeine. It's not necessarily present in all poppy seeds but there are many seeds on the market with high levels. I found this paper with a really thorough assessment of morphine content and the biological impact of that: Update of the Scientific Opinion on opium alkaloids in poppy seeds The lowest known therapeutic dose is 1.9 mg for a 70-kg person and the acute reference dose would be 0.7 mg for that person. If you have high-morphine seeds, you could end up with as much as 5 mg morphine in 36 grams. Morphine content can be reduced by washing and possibly finding a high-quality source that tests their seeds. Secondly I don't see any papers testing the bioavailability of the calcium in poppy seeds. The closest thing with experimental data is sesame seeds, which have 20% bioavailability. (from this paper). Cow's milk is 30% bioavailable. So you would just want to be aware of that when you're tracking your dietary intakes. Eating only one meal a day, you'd have to consider the oxalate content of the meal as well because foods with very high oxalates (like raw spinach) can block the absorption of calcium from foods eaten alongside them. My personal move would be to not consume poppy seeds every day, since there are other seeds with more evidence for being beneficial like pumpkin, chia, and flax and no morphine concerns. Also, I just supplement calcium.

Bioequivalence: The article is disproving the myth that the range is 45%. However it states that drugs differed on average in one study by 3.5%, and 20% differ by more than 5%. They estimate that 10% is the upper bound that could be approved, which is what I said. Is that a big deal? I don't know. Maybe it could be for some drugs. Recalls: I said the Wellbutrin was ineffective. I didn't say it was dangerous. That is simply evidence that generics on the market can differ enough to matter to patients.

Generic drugs can have a bioavailability that differs from the brand name by up to ~10% on either side. According to this article 20% of drugs differ by more than 5%. And, those numbers come from the original studies done to get the generics approved by the FDA, they don't keep testing bioequivalence regularly as part of quality control. This is especially relevant for time-release medications, because you can't just analyze the contents of the pill, you need to test it in humans to get the blood concentration data. There are some special regulations in place for some drugs with a narrow therapeutic index. I only know about psychiatric drugs - but the FDA has recalled generics of Wellbutrin several times in the past few years for being ineffective (2018, 2016, 2012). Those investigations were initiated by collections of complaints from patients. On top of that, you can find people all over the internet with anecdotes of feeling differences between brand name and generic antidepressants, or between different generic manufacturers. Could be placebo, could be a response to inactive ingredients in the drug (which are not required to be the same), or they are releasing differently or contain different concentrations of the active ingredients. That's for antidepressants, where you are supposed to notice the effects of the drug. If you can't notice it you could end up taking something for years that causes kidney cancer, apparently. Seems like it would be preferable to prevent this from happening at all rather than letting them sue for damages after the fact. I'm not opposed to generics, I take them, but it's another reason to try to avoid prescription medications in general.

It had the same objection to the old bmi as you, but determined that the best exponent is actually 2.5. Using a cube would raise the lower bound of healthy weight even further for someone of above average height. This is called extreme hunger and happens to most eating disorder survivors. It will remain as long as you are underweight and go away with time if you continue eating and gaining weight.

If you want a cubed number you can use the new bmi. According to it you are even more underweight than by the original method.

If you eat a lot of whole grains, legumes, and greens, you will get a lot of betaine. Betaine is one of the metabolites of choline used for methylation, so eating it directly contributes to the choline requirement. According to Chris Masterjohn it's good for up to half of the requirement, so you'd only need 275 mg choline.