Alex K Chen Posted November 16, 2023 Report Share Edit Posted November 16, 2023 (edited) https://www.genecards.org/cgi-bin/carddisp.pl?gene=ST6GAL1 https://www.frontiersin.org/articles/10.3389/fnins.2020.572965/full https://glycanage.com/glycanhub/podcast/season-1/glycans-and-neurodegenerative-diseases-a-new-perspective-on-alzheimers-with-prof-ronald-schnaar Quote During brain development, the ganglioside pattern changes from the prevalence of the simple gangliosides GM3 and GD3 to more complex ones such as GD1a and GT1b [66] (for structures, see Figures Figures77 and and11).11). Ganglioside content and composition of the brain change also during aging: for example, the amount of lipid-bound sialic acid decreased from 1070 μg/g wet weight in a 25-year-old healthy proband to 380 μg/g wet weight in a 85-year-old individual. Despite this, the concentrations of GQ1b, GT1b, and GD1b increase with age at the expense of GM1 and GD1a GM1 = 4 chain, GM3 = 1chain https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-021-02374-x Edited November 17, 2023 by InquilineKea Quote Link to comment Share on other sites More sharing options...
Alex K Chen Posted November 16, 2023 Author Report Share Edit Posted November 16, 2023 (edited) Edited November 17, 2023 by InquilineKea Quote Link to comment Share on other sites More sharing options...
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