Alex K Chen Posted February 26, 2023 Report Share Edit Posted February 26, 2023 (edited) wow this sounds SO much similar to RDW Quote 3.3. EVs Cargoes, Concentrations, and Sizes in Aging and Age-Related Pathologies Like senescent cells, damaged cells tend to release more EVs [88,89,90]. Although EV cargo reflects their parental cell, EV cargo becomes more heterogeneous when derived from damaged or senescent cells instead of healthy cells [63]. Therefore, these cargoes could also be used as biomarkers of aging and age-associated diseases [7,48]. A recent study showed that plasma from young and old mice presents EVs with different cargoes, concentrations, and sizes [7,81]. Thus, aging and its associated diseases can modify the released number of EVs and their cargo, thereby compromising homeostasis [19]. Recently, other studies have shown that particle number and size delivery depend on cell derivation and senescence triggers [7]. Of interest, EV content is heterogeneous and depends on the type of EV and the aging microenvironment. Therefore, due to the ubiquitous presentation or tissue-specific manner, this cargo could also be used as a biomarker of the elderly and aging-associated diseases [7,48]. Accordingly, the heterogenous EV content in aging is a potential biomarker of age-associated diseases in the elderly [7,48]. https://www.mdpi.com/1422-0067/24/4/4250 === https://isevjournals.onlinelibrary.wiley.com/doi/full/10.1002/jex2.154 michael greger has more to say in his last book Edited May 4 by Alex K Chen Quote Link to comment Share on other sites More sharing options...
Recommended Posts