Search the Community
Showing results for tags 'mtor'.
Found 1 result
-
Hi all, I'm starting this thread which is another offshoot of my mTOR obsession. I find this protein more fascinating than ever. It has been described as an ON/OFF switch, but actually it's more like a DIMMER. It can be downregulated, emanating a soft, pale light (activity) whereas it can be upregulated, providing a bright light. In scientific terms, it's activity is measured by the phoshorylation ratio (phosphorylated/unphosphorylated mTOR proteins) in every single organ/tissue. Chronical downregulation or upregulation can be bad and result in sickness or degenerative or neoplastic disease. Whereas a wise tweaking of such a metabolic dimmer can result in more healthspan and longevity. In the central nervous system (CNS) a fair level of mTOR activity is believed to mantain neurogenesis and prevent cognitive impairment. I'm going to post some literature and some practical consideration upon the literature. We've seen that we can upregulate mTOR in skeletal muscles by exercise thru the mechanoreceptors signal and make muscles grow, or preventing them from atrophying. We've seen that we can upregulate mTOR in the BAT tissue by cold exposure thru the norepinephrine receptors signal, making BAT increase in mass and reaping the beneficial results. How can we upregulate mTOR in the CNS?
