Gordo

I'd love to know what the monthly costs are (burn rate) and how much $ is left in the CRSociety account, so we can know in advance, approximately when the forum will disappear again absent a new cash infusion or fundraising.

Jim - I think the goal for most here is healthspan with HOPE that future technology might extend life. There is a possibility that AI / machine super intelligence might somehow play a factor in all of this, but no one knows (you could almost as easily believe AI / machine super intelligence will end humanity, haha). I agree with Dean, do all the Dr. G you want, its not going to get you (or him) to 120. One thing you might want to track is your DunedinPACE which may indicate your rate of aging. This could in theory at least, give you a pretty good idea of how long you will live (without some yet to be available technology to change your pace of aging). https://www.rejuvenationolympics.com/dunedin-pace

👍 Ah, I guess he had already started OpenAI back then and also had high visibility via Y Combiner (as its president) so my initial hunch was probably correct then about the film poking fun at him. I think you would like it.

https://www.imdb.com/title/tt4693358/?ref_=nv_sr_srsg_0_tt_8_nm_0_in_0_q_otherlife Otherlife was good, never heard of it until Prime recommended it last night. Here's a really strange thing about it, the "villain" is named Sam and he looks a LOT like Sam Altman. I thought it was an intentional joke sort of thing, then I found out this movie came out in 2017, Sam Altman didn't become CEO of OpenAI until 2019, I don't think he was on anyone's radar in 2017, much less being cast as the villain of AI back then. Things that make you wonder 🤔

I disagree, we have a pretty solid idea that outside of new technology that may come along in the future, the current natural limit to human lifespan is about 120 years (which is oddly mentioned in an ancient book many people revere, haha).

Cool, I was trying to check in every couple weeks just to see if it would come back online but had started to think it was gone forever. Thanks to whomever paid the bill to turn it back on! I like the community here. Agree it would be nice to get a searchable archive somehow out there somewhere on the web. Also wondering if there is a free hosting option so this doesn't happen again?

Good stuff. I plan to do DunedinPACE testing, would be nice to see lots more people doing this so we can actually have some solid evidence of value for different interventions.

Hate to feed Alex's paranoia but... p.s. I'm also interested in the unnamed series mentioned above, but the Alex 🤖 seems to have difficulty interacting with others 😭

New evidence has emerged recently about the Covid origins coverup and it's looking very bad for all involved, this was discussed starting at the 18:41 mark of the All In podcast Also covered by lots of mainstream media: https://www.politico.com/news/2024/06/02/fauci-covid-research-investigative-panel-00161109

Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomesCold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes Lee, H.J., Alirzayeva, H., Koyuncu, S. et al. Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes. Nat Aging 3, 546–566 (2023). https://doi.org/10.1038/s43587-023-00383-4 Abstract Aging is a primary risk factor for neurodegenerative disorders that involve protein aggregation. Because lowering body temperature is one of the most effective mechanisms to extend longevity in both poikilotherms and homeotherms, a better understanding of cold-induced changes can lead to converging modifiers of pathological protein aggregation. Here, we find that cold temperature (15 °C) selectively induces the trypsin-like activity of the proteasome in Caenorhabditis elegans through PSME-3, the worm orthologue of human PA28γ/PSME3. This proteasome activator is required for cold-induced longevity and ameliorates age-related deficits in protein degradation. Moreover, cold-induced PA28γ/PSME-3 diminishes protein aggregation in C. elegans models of age-related diseases such as Huntington’s and amyotrophic lateral sclerosis. Notably, exposure of human cells to moderate cold temperature (36 °C) also activates trypsin-like activity through PA28γ/PSME3, reducing disease-related protein aggregation and neurodegeneration. Together, our findings reveal a beneficial role of cold temperature that crosses evolutionary boundaries with potential implications for multi-disease prevention.

Common Blood Pressure Drug Increases Lifespan And Slows Aging in Animals https://www.sciencealert.com/common-blood-pressure-drug-increases-lifespan-and-slows-aging-in-animals https://en.m.wikipedia.org/wiki/Rilmenidine I'd never heard of this drug before but was interested based on it being described as a CR mimetic and it has antiinflammatory properties plus apparently very low reported side effects. There should be plenty of human data out there considering it is already prescribed to many people...

Thanks. This was 2 weeks back, so they are fully recovered now and so far no one else in the family got it. It does make me think about vaccines again though.

👍 I like these profiles of longevity olympians, but the fact is he is still being beaten by Julie Gibson Clark who doesn't take rapamycin or 120 supplements a day 😇 And the other sad fact is that all of these routines will only get you to about age 92 give or take a few years.

Ignoring timeline because its going to take quite a lot of time, I DO in fact think the "universal basic income" idea will become the norm, but "basic" is not the right word, I'm no Elon Musk fanboy and don't own a Tesla, but I kind of agree with him that eventually "universal high incomes" are coming: https://finance.yahoo.com/news/elon-musk-predicts-universal-high-160015532.html I don't see how this DOESN'T happen, I mean for certain bots will be providing everything humans want, including food and shelter and everything else you can think of. In some respects we already have a sort of UBI in place right now with millions getting social security, medicare/medicaid, SNAP (food stamps), etc. But yea, I know, with $34 trillion in debt and that number already growing a couple $trillion more each year, I don't know how this really plays out, at some point will are going to have insane inflation like a banana republic country. I think some in the investor class are seeing technology as our "way out" of the debt bomb situation we are already in, i.e. a productivity miracle should in theory solve a debt crisis, if in fact everything essentially can be produced for nearly free. I do believe at some distant point in the future money won't even exist (see: The Economic Lessons of Star Trek’s Money-Free Society )

I'm excited and optimistic about AI and humanoid robots. That Figure demo posted above is pretty impressive assuming it's not a fraud/hoax. Given how quickly things seem to be progressing right now, it's not hard to imagine very capable humanoid robots taking over many jobs within 10 years and eventually taking over most jobs. I don't fear this, I think it will lead to a new era of prosperity where traditional work becomes optional or obsolete. I agree though that right now the hype cycle is amped up to an 11, and investors are likely to be disappointed as in all past hype cycles. But then again, there's something about this that genuinely does seem different, when have we ever had the computing power to simulate or surpass a human brain 🧠? Never, but now all of the sudden we seem to be pretty close. If anything I'd guess the average person is underestimating how much things are going to change over the next 30 years. But maybe I'm also overestimating how fast it can happen... perhaps the real hard core AI will still be stuck in massive power sucking data centers and unable to make it out into the world via robotics and we just end up with a lot of expensive novelty bots that can clean our houses, do dishes and laundry and answer questions like ChatGPT does 🤔

My brother who is only age 52 just had to get a pacemaker, he says his heart problems started right after getting Covid. I hadn't heard of this link but a quick search turned up: https://news.weill.cornell.edu/news/2022/04/are-covid-19-linked-arrhythmias-caused-by-viral-damage-to-the-heart’s-pacemaker-cells My wife and son just got Covid for the second time by the way, and it was just as bad as the first time they had it (my son was in bed for 4 days). I tried my best to stay away from them, dropping off food at their doors and getting away 😂. I managed to avoid it. This version did not cause much coughing or sneezing, mostly fever, sore throat, fatigue. Super bright positive on the pcr test though.

So being on immunosuppressive drugs 24/7 for life has no downside? Who needs an immune system anyway? 🤔

A study says intermittent fasting is making people drop dead. Oh, come on https://www.statnews.com/2024/03/19/intermittent-fasting-study-heart-risk/

Guerrero: This California millionaire is peddling eternal life. Why do so many people believe him? Valter Longo, director of the USC Longevity Institute and professor of biological science, says some of Johnson’s treatment combinations, such as the 100-plus supplements, could be harmful. “You can cause short-term benefits, but eventually that will probably turn into long-term problems,” he told me. I tend to agree with Longo on this. Already we have other examples now of people achieving better aging biomarkers than BJ with less expensive, and less supplemented routines. I don't really think of him as pedling eternal life though, he is doing lots of experiments with his own body in hopes of finding things that will optimize his health but seems to fully acknowledge that it's going to take some super intelligence AI to have any real chance of solving this problem. He is probably right about that.

There are some interesting comments in the above vid, for example she mentions studies showing you can activate brown fat just by putting your hand alone into a bucket of cold water. There is value in fluctuating your temperature throughout the day to build brown fat. And sleeping in a cold room, even with clothes and a heavy blanket still works to activate brown fat as long as your face is exposed to the cold air.

Full version:

That's awesome, I would like to plant more variety, definitely interested in kiwi. There is a huge wild patch of pawpaw trees in the woods behind my house and the fruit is terrible, I would like to graft some good scion wood to some of those trees. I did hand pollinate the trees in my yard last year just to be sure, but there were tons of pollinator flies on the flowers so I think I should not really need to do that. I also planted seeds all over the place just for fun, especially along a local river bank.