Saul

I'm on CR; I don't need or want semiglutide. -- Saul

I'll be 85 yo in 6 weeks. I'm in excellent health, and have been practicing CR for about 30 years. I don't intend toexperiment with taking Rappa -- but I'm very interested in Matt Kaberlien's work on the effects of Rappa on large domestic dogs (which are short-lived mammals; it's a placebo controlled trial, that has been cleverly set up to not require approval by any government agencies -- people volunteer their pet dogs). -- Saul

I agree. Kenton's comment makes sense, too. I have a complimentary subscription to the NYT (a courtesy extended to me by virtue of being a [fully employed] prof at the University of Rochester -- and I had been considering posting that same article to the NYT. -- Saul

Hi Ash! Dean's opinions about the monkey studies are just that: Dean's opinions. I wouldn't necessarily take them seriously. (Anyway, Dean's opinions work for Dean). -- Saul

I have a high opinion of Kaberlien, and a vry low opinion of Atiyah. -- Saul

I basically agree with Tom. I'm 84 3/4, in excellent health. I also agree with Cory's post, about Al's post, noting the inportance of adopting a creative and self-transcendent perspective on life can positively impact gene expression. Both of my brothers have passed away -- both my older brother and my younger brother. My parents, and all relatives that I know about, did not have extraordinary lifespans or healthspans. Like Tom, I exercise, though I don't enjoy it. I do enjoy calorie restriction, and have been practicing CR for a long time, and intend to continue doing so. -- Saul

Hi McCoy! Sounds like a ketotic diet. They do make it easy to lose weight; but Luigi, in his original posts, discouraged them. (Evidence is that the lipid levels tend to be bad.) Byt maybe it work well for you. -- Saul

Gordo, The immune suppressive factor in rapa is negligible for helthy people; so it's conceivable that rapa might be interesting. I asked Matt when he gave a talk at the University of Rochester's annual aging conference, whether he thought that CR and rapa might go together. He said that he never could get funding for such a study. The dog study is possible, since it simply depends on large dog owners volunteering to allow their pet to enter the study. Since large dogs have short lifespans, there hopefully might be some useful data in not too long a time period. If, as Matt suspects, rapa appears to improve the expected lifespan and heathspan of large dogs, it would certainly be interesting. -- Saul

IMO, breathing in nanoparticles is a very bad idea for your lungs. Much less clear is, whether or not eating foods containing nanoparticles of plastics is a significant threat to health (obviously depends ona lot of factors -- including what plastic; how big are the pieces; etc). Animal studies would be interesting. But I would guess: Giving up your raw broccoli, because maybe there are inert nonoplastic particles in it, is unwise. -- Saul

Very believable. -- Saul

I believe that you're almost certainly correct. -- Saul

I'm participating in a series of 8 meetings of about 10 people (faculty, grad students; med school plus college of arts and sciences) on AI. My favorite tool is Microsoft Bing Copilot; IMO, it's the best. (Possibly, I'll be able to use it to write Midterm Exams easiy:) Happily, I think University of Rochester is getting a site license. -- Saul

It seems extremely likely to me that each of our organs ages at a different rate; and that these rates differ for different people. I've seen good articles on this topic in the past; here's IMO a good one posted today in the Wall Street Journal: https://www.wsj.com/health/wellness/aging-biological-age-organs-health-9b6a4798?mod=hp_lead_pos11 -- Saul

Well said. Nice Find. __ Saul

I would guess that, the younger the animal, the more pro-growth stuff -- bad for adults seeking increased healthspan and lifespan. And no animal is younger then an egg. -- Saul